题 目:Multicomponent Self-Assembly of a Giant Heterometallic Polyoxotungstate Supercluster with Antitumor Activity
作 者:Jian-Cai Liu, Jie-Fei Wang, Qing Han, Ping Shangguan, Lu-Lu Liu, Li-Juan Chen, Jun-Wei Zhao,* Carsten Streb,* and Yu-Fei Song*
刊 名:Angew. Chem. Int. Ed.
年卷页:2021,60,11153-11157.
影响因子：15.336
摘 要： The hierarchical aggregation of molecular nanostructures from multiple components is a grand synthetic challenge, which requires highly selective linkage control. We demonstrate how two orthogonal linkage groups, that is, organotin and lanthanide cations, can be used to drive the aggregation of a giant molecular metal oxide superstructure. The title compound {[(Sn(CH3)2)2O]4{[CeW5O18] [TeW4O16]- [CeSn(CH3)2]4[TeW8O31]4}2}46-(1a) features dimensions of ca. 2.2×2.3×3.4 nm3 and a molecular weight of ca. 25 kDa. Structural analysis shows the hierarchical aggregation from several independent subunits. Initial biomedical tests show that 1 features an inhibitory effect on the proliferation of HeLa cells based on an apoptosis pathway. In vivo experiments in mice reveal the antiproliferative activity of 1 and open new paths for further development of this new compound class.
文章链接：https://onlinelibrary.wiley.com/doi/10.1002/anie.202017318
