李明雪

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基本信息


姓名:李明雪

职称:教授

导师情况:博士生导师

办公室:化学化工学院433

E-Maillimingxue@henu.edu.cn

个人简介

李明雪南京大学博士,博导,河南大学特聘教授,河南省教育厅学术技术带头人,河南省高等学校青年骨干教师。承担《无机及分析化学》、 《无机化学》、 《工程化学基础》、 《无机化学实验》等课程。主持国家级、省级、厅级等自然科学基金等项目11项,在 Inorg. Chem.Dalton TransEur. J. Med..ChemJ. Inorg. BiochemDyes Pigments Synth. Met.Bioorg. Med. Chem. Lett J. Organomet. Chem.等期刊上发表SCI收录论文80余篇;参编教材2部;获河南省科技进步奖1项,获河南省第十届自然科学优秀论文奖2项;授权国家发明专利2项。一直致力于聚金属氧酸盐、二茂铁和缩氨基硫脲等功能配合物及其纳米粒子的合成与电化学、生物活性、催化等性能研究。

研究方向

多酸化学/纳米材料/无机药物化学/催化等。

承担的主要项目

1. 缩氨基硫脲修饰的Strandberg型多钼氧簇有机-无机复合物的设计和生物活性评价(21671055),国家自然科学金面上项目,2017.01-2020.12,主持。

2. 杂环缩氨基硫脲及其金属配合物的合成,晶体结构和生物活性(21071043),国家自然科学基金面上资助项目,2011.01-2013.12,主持。

3. 双缩二氨基硫脲Schiff碱衍生物的设计和生物活性(132300410146),河南省科技厅基础与前沿,2013.02-2015.02,主持。

4. 杂环缩硫脲及其金属配合物的设计和抗癌活性研究(102300410093),河南省科技厅基础前沿,2010.01-2012.12,主持。

5. 嫁接缩氨基硫脲的多酸化合物的合成和生物活性评价(14B150028),河南省教育厅科学技术研究重点项目,2014.01-2017.12,主持。

6. 杂环硫脲及其金属配合物的设计和抗癌活性研究(2010B150003),河南省教育厅自然科学研究指导计划项目,2010.01-2012.01,主持。

7. 缩硫脲及其金属配合物的设计和生物活性(20090460847) ,第46批中国博士后科学基金资助项目,2009.08 -2011.08,主持。

8. 杂环缩硫脲及其金属配合物的设计和抗癌活性研究(2009GGJS-025),河南省高等学校青年骨干教师资助项目,2009.12-2012.12,主持。

9. 杂环缩氨基硫脲及其金属配合物的合成和生物活性评价,2010年河南省博士后项目启动经费一等资助,主持。

10. 茂铁基金属配合物的合成和性质研究(0611011900),河南省科技厅基础与前沿技术研究计划项目,2006.1-2009.1,主持。

代表性成果

1.Yan-Xue Tai, Yu-Mei Ji, Yan-Li Lu, Ming-Xue Li*, Yuan-Yuan Wu, Qiu-Xia Han*Cadmium(II) and indium(III) complexes derived from 2-benzoylpyridine N(4)-cyclohexylthiosemicarbazone: Synthesis, crystal structures, spectroscopic characterization and cytotoxicitySynth. Met.2016, 219,109-114.

2. Nan Zhang, Yanxue Tai, Mingxue Li*, et alMain group bismuth(III), gallium(III) and diorganotin(IV) complexes derived from bis(2-acetylpyrazine)thiocarbonohydrazone: synthesis, crystal structures and biological evaluation, Dalton Trans., 2014, 43, 5182-5189.

3. Yan-Ke Li, Min Yang, Ming-Xue Li*, Han Yu, He-Chen Wu, Song Qiang Xie* Synthesis, crystal structure and biological evaluation of a main group seven-coordinated bismuth(III) complex with 2-acetylpyridine N4-phenylthiosemicarbazone Bioorg. Med. Chem. Lett., 2013, 23(8), 2288-2292.

4. Mingxue Li*, Min Yang, Jingyang Niu, et al, A Nine-Coordinated Bismuth(III) Complex Derived from Pentadentate 2,6-Diacetylpyridine Bis(4N-methylthiosemicarbazone):Crystal Structure and Both in Vitro and in Vivo Biological Evaluation, Inorg. Chem., 2012, 51, 12521-12526.

5. Ming-Xue Li, Li-Zhi Zhang, Min Yang, Jing-Yang Niu, Jing Zhou. Synthesis, crystal structures, in vitro biological evaluation of zinc(II) and bismuth(III) complexes of 2-acetylpyrazine N(4)-phenylthiosemicarbazone, Bioorg. Med. Chem. Lett., 2012, 22, 2418-2423.

6. Mingxue Li*, Yanli Lu, Min Yang, et al, One dodecahedral bismuth(III) complex derived from 2-acetylpyridine N(4)-pyridylthiosemicarbazone: synthesis, crystal structure and biological evaluation, Dalton Trans., 2012, 41, 12882-12887.

7. Mingxue Li, Lizhi Zhang, Chunling Chen, et al, Synthesis, crystal structures, and biological evaluation of CuII and ZnII complexes of 2-benzoylpyridine Schiff bases derived from S-methyl- and S-phenyldithiocarbazates, J. Inorg. Biochem., 2012, 106, 117-125.

8. Mingxue Li*, Lizhi Zhang, Dong Zhang, et al, Synthesis, crystal structures, and biological evaluation of manganese(II) and nickel(II) complexes of4-cyclohexyl-1-(1-(pyrazin-2-yl)ethylidene) thiosemicarbazide, Eur. J. Med. Chem., 2011, 46, 4383-4390.

9. Ming-Xue Li, Dong Zhang, Li-Zhi Zhang, Jing-Yang Niu, Bian-Sheng Ji, Diorganotin(IV) complexes with 2-benzoylpyridine and 2-acetylpyrazine N(4)-phenylthiosemicarbazones: Synthesis, crystal structures and biological activities,  J. Organomet. Chem. 2011, 696(4), 852-858.

10. Ming-Xue Li, Chun-Ling Chen , Dong Zhang , Jing-Yang Niu , Bian-Sheng Ji, Mn(II), Co(II) and Zn(II) Complexes with heterocyclic substituted thiosemicarbazones: synthesis, characterization, X-ray crystal structures and antitumor comparison Eur. J. Med. Chem., 2010453169-3177.

11. Ming-Xue Li*, Dong Zhang, Li-Zhi Zhang, Jing-Yang Niu, Bian-Sheng Ji Synthesis, crystal structures and biological activities of 2-acetylpyridine N(4)-cyclohexylthiosemicarbazone and its manganese(II) and nickel(II) complexes. Inorg. Chem. Commun. 2010,13, 1572-1575.

12. Ming-Xue Li* , Dong Zhang, Li-Zhi Zhang, Jing-Yang NiuSynthesis, crystal structures, and biological activities of 2-thiophene N(4)-methylthiosemicarbazone and its unusual hexanuclear silver(I) clusterInorg. Chem. Commun. 2010,13, 1268-1271.

13. Ming-xue Li, Chun-ling Chen, Chun-sheng Ling, Jing Zhou, Bian-sheng Ji, Yan-juan Wu, Jing-yang Niu. Cytotoxicity and structure-activity relationships of four a-N-heterocyclic thiosemicarbazone derivatives crystal structureof 2-acetylpyrazine thiosemicarbazone Bioorg. Med. Chem. Lett., 2009, 19, 2704-2706.

发明专利

1. 李明雪,陈利娟,罗婕,赵俊伟,刘建彩,张芳,铜-铕异金属取代砷钨酸盐及其制备方法和应用,中国授权发明专利,ZL201510035099.320164月。

2.赵俊伟,李明雪,陈利娟,李彦克,张丽枝,二(2-乙酰吡嗪基)硫代缩二氨基脲及其铋(III)配合物的制备方法及应用,中国授权发明专利,ZL201210493229.420149月。